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Other Ingredients: Gelatin, Rice Flour.
Directions: Take 2 capsules twice per day with food.
Brite by EvoMuse
Want to convert your fat into thermogenic fat? We all have some white fat cells that have brown in them and thus behave like brown stubborn fat cells. Brite by EvoMuse targets these fat cells using all available pathways. Using Brite can assist in fat loss and mimicking of the lean body type, that burns fat fast, has a high metabolism and stays lean! Get that long term lean, as results for this product last. Order Brite and get the white adipose tissue to turn brite and active and get lean now!
- Burn Fat
- Non Stim
- Researched Formula
- Convert White Fat into Thermogenic Fat
- Reduce Inflammation
- Optimize Metabolism
Butcher’s Broom Extract
Butcher’s Broom is an herb, also known as Ruscus aculeatus. It gets its name from the practice of butchers using it for its supposed antibacterial properties to clean their cutting boards. It has been used in traditional medicine for its vasoconstrictive and anti-inflammatory actions (reducing swelling, preventing hemorrhoids, etc.).
The plant contains a variety of saponins, which have been shown to activate alpha-1 adrenergic receptors and stimulate the release of norepinephrine. It also has a protective effect on capillaries, strengthens blood vessels, and helps maintain healthy circulation.
As discussed previously, this alpha-1 activation is important and has been shown to shift preadipocytes to beige cells as opposed to white adipose tissue. As well, recent research shows that when hibernating animals’ thermosensitive mechanisms detect ambient and body temperatures falling under threshold, the SNS releases norepinephrine to activate BAT in order to maintain viable body temperatures.
SREBPs are major transcription factors involved in adipogenic differentiation from precursor cells, as well as factors in fat storage. Andrographolides downregulate the expression of SREBPs and target genes in BAT, decreasing fat storage and encouraging differentiation to brite cells. Andrographolides also target the activation of the TRPV4 and TRPV1 receptors. Finally, andrographolides trigger an increase in Wnt/b-catenin signaling, contributing to the WAT browning process.
Safflower Leaf Extract
By enhancing angiogenesis through the VEGF signaling pathway, SLE promotes differentiation from precursor cells away from the WAT pathway.
Several studies have looked at the effect of SLE on rodents given obesogenic diets, with a long list of benefits elucidated. By promoting the browning of subcutaneous WAT and activating the IRS1/AKT/GSK3b pathway, the SLE groups saw reduced body fat mass, inflammation, fasting blood glucose, and total cholesterol and triglycerides, with an increase in insulin sensitivity.
Another study, in addition to reaffirming the above findings, also showed an interesting benefit in gut function by increasing short chain fatty acid production and improving gut microbiota.
Gypenosides are saponins found in the Jiaogulan plant. This ingredient targets both WAT and BAT. We get WAT browning, and an increase in fat oxidation genes in both WAT and BAT. Obesogenic diet mice treated with Gypenosides had a significantly reduced bodyweight vs. control, with lower cholesterol and insulin resistance. Interestingly, similar to Safflower Leaf Extract, research also shows improved gut microbiota with Gypenosides supplementation.
Aside from b3 adrenergic receptor activation, the other most important way to start the browning process of WAT browning, as previously discussed, is through cold exposure. By exposing the body to cold temperatures long term, it activates the TRPM8 receptor, which triggers browning in order to more effectively use WAT to create body warmth.
TRPM8 activation also enhances the thermogenic function of brown adipocytes through UCP1 and the b-adrenergic pathway.
Menthol mimics long-term cold exposure by activating the TRPM8 channel, and has been shown to induce WAT browning, as well as an upregulation in BAT thermogenesis. This has been shown to increase core temperature, reduce body fat and improve glucose metabolism.
Piperonal is an active constituent of piper nigrum seeds and also found in vanilla. It has been called a “potent antiobesity agent”, and is another ingredient in the formula that brings the one-two punch of inhibiting preadipocyte differentiation and upregulating thermogenic genes in WAT.
In rodents fed obesogenic diets, Piperonal did everything you could hope for. It attenuated body fat gain, adipocyte size, and glucose/insulin elevation. It stimulated also AMPK and elevated circulating adiponectin.
Black Pepper Extract
TRPV1 is a capsaicin and vanilloid receptor in the body that is responsible for detection and regulation of body temperature and pain. More recently this receptor has been identified as a major player in obesity and body fat regulation. Stimulation of TRPV1 has been shown to upregulate BAT and increase fat oxidation and energy expenditure. TRPA1 is a similar receptor that functions to recognize cold and pain.
Piperine, as well as several other compounds in black pepper have been shown to be TRPV1 and TRPA1 agonists, with an even greater efficacy than capsaicin.
Trans-Cinnamaldehyde is a pungent compound from cinnamon or dried cassia bark. TC has been shown to increase UCP1 in both WAT and BAT, inducing browning of WAT cells. It also activates the cold receptor TRPA1. Back to those rodents fed obesogenic diets, TC inhibited hypertrophy of adipose cells, decreased body fat (including visceral fat), decreased voluntary food intake, and improved insulin sensitivity.
Wasabi Leaf Extract
From the Japanese Wasabi plant, this leaf extract targets body fat loss in a few different ways. One of the most important ways to cause a browning of WAT is through the b3 adrenergic system. WLE has been shown to upregulate expression of the b3 adrenergic receptors in BAT.
In multiple studies looking at mice and rats fed an obesogenic diet, groups given WLE showed significantly less body fat. Fat storage markers were suppressed (SREBP-1c, PPARy, C/EBPa), and thermogenic/fat burning markers were enhanced (PPARa, adiponectin, AMPK). Adipose cell hypertrophy was inhibited, and fatty acid oxidation was enhanced.
Sesamol is a phenol derivative of sesame oil with antioxidant and anti-inflammatory properties. This is another ingredient in the formula with the aforementioned two-pronged attack. It downregulates adipogenic differentiation factors (C/EBPa, PPARy, SREBP-1) and decreases fat accumulating enzymes like fatty acid synthase (FAS), while upregulating fat oxidizing enzymes like HSL, LPL and AMPK. In mice on an obesogenic diet, it decreased fat mass and adipocyte size in both WAT and BAT by increasing UCP1 and PCG1a.
Strawberry Fruit Extract
A new and surprising set of studies recently done on Strawberry Fruit yielded potent results in the area of brite formation. A methanol extract proved incredibly potent in triggering brite formation in adipocytes, arrest of development of preadipocytes into mature fat cells, AMPK activation in mature adipocytes as well as SIRT1/PGC1a/and UCP1. The extract also showed potent triggering of mitochondrial biogenesis in adipocytes, probably the biggest indicator of browning as this is the actual site of heat generation.
Raspberry Fruit Extract
Recent discoveries in AMP kinase, that potent pathway activated during demanding exercise which facilitate fat burning and metabolic adaptation, yielded some interesting observations—notably a subtype of AMPK that was adipocyte specific. If you are beyond a certain level of understanding, you will already have your interest piqued. You see, AMPK activation (the dreaded cardio catabolism), in conventional understanding, prevents mTOR activation, which normally short circuits protein synthesis. This newly discovered subtype of the AMPK receptor, as mentioned, is adipocyte specific—meaning we can hit this HARD, and shrink those fat cells rapidly, without deleterious effects on muscle grown. The specialized Raspberry Fruit extract we have used is insanely potent, not only triggering previously mentioned pathways (UCP1, non-shivering thermogenesis, etc.) but preferentially activates this new AMPK-alpha1 subtype. We are able to combine this in a way that will minimize that “do I want to build muscle or burn fat” conundrum, and allow for best of both worlds results.
Mulberry Leaf Extract
One of the superstars of this new version of BRITE Capsules is the Mulberry Leaf Extract. In addition to hitting some of the above pathways, the unique polyphenols and other compounds not only contribute to ideal Leptin signaling and massive brite cell activation/uncoupling, but manipulate our gut microbiota to push towards a lean phenotype. In our guts there dwell different subtypes of bacteria that act as master controllers of things like glucose metabolism, inflammatory state, etc. These two subtypes (among others: see Güt Health) are called Bacteroidetes and Firmicutes. When the Firmicutes dominate then “cute” is not where we wind up. These bacteria cause metabolic dysfunction and obesity. By enhancing the Bacteroidetes domination, our bodies reduce inflammation, normalize glucose metabolism, reduce metabolic disorder, and re-express that lean phenotype we all crave.