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​The Ultimate Guide to R-ALA: Benefits, Best Supplement, and More

​The Ultimate Guide to R-ALA: Benefits, Best Supplement, and More

Posted by Leonard Shemtob on Feb 23, 2024

Imagine unlocking a powerful tool to combat aging, disease, and everyday stress – all while supporting your body's natural defenses against oxidation. In recent years, researchers have been uncovering exciting evidence about a unique antioxidant called R-ALA (R-alpha lipoic acid). 

This potent compound has shown promise in promoting healthier cells, boosting energy levels, and potentially even extending lifespan.

In this comprehensive guide, we will delve into the world of alpha lipoic acid, exploring its benefits, the best supplement containing it, and why it should be considered part of any wellness routine. As we journey through the science behind R-ALA, you'll discover why this remarkable substance is gaining attention from both scientists and consumers alike.

So, let's embark on this exploration together and learn more about the incredible power of alpha-lipoic acid!

Short Summary

  • Unlocking Potential: Explore the power of R-alpha lipoic acid as a potent antioxidant, unlocking its ability to combat aging, support natural defenses, and mitigate everyday stress.
  • Evidence-Based Benefits: Delve into the scientific evidence showcasing R-ALA's potential to promote healthier cells, boost energy levels, and even extend lifespan.
  • Best Supplements Unveiled: Discover the top-rated supplement containing alpha-lipoic acid, “R-ALA R-Lipoic Acid by Hi-Tech Pharmaceuticals,” providing insights into the ideal choices for incorporating this powerful compound into your wellness routine.
  • Unlocking Your Potential: Explore how incorporating alpha-lipoic acid into your routine could support your wellness journey and empower you to reach your health goals.

Understanding Alpha Lipoic Acid

Alpha Lipoic Acid (ALA), AKA thioctic acid, is a naturally occurring compound synthesized in limited quantities by the human body. Additionally, it is present in certain foods like spinach, broccoli, and organ meats. Serving as a potent antioxidant, ALA aids in shielding cells against damage caused by free radicals.

Moreover, it contributes to energy production by facilitating the conversion of glucose into usable energy. Unlike other antioxidants that work only in water (such as vitamin C) or fatty tissues (such as vitamin E), Alpha Lipoic Acid (ALA) is unique in that it is both fat and water-soluble. This means that ALA can function throughout the body.

ALA is accessible in supplement form and is commonly utilized in managing conditions such as diabetes, neuropathy, and liver disease. R-alpha lipoic Acid (R-ALA) is a specific form of ALA that is more easily absorbed by the body and has been shown to have greater antioxidant activity than other forms of ALA.

Benefits of Alpha Lipoic Acid (ALA)

Antioxidant Defense: ALA acts as a potent antioxidant, protecting your body cells from damage caused by free radicals. It increases antioxidant capacity, helps decrease inflammation, and improves cells’ ability to defend against pathogens and oxidative stress. This defense mechanism plays a crucial role in maintaining overall cellular health.

Energy Production: ALA contributes to energy production by aiding in the conversion of glucose into usable energy. This function is essential for supporting various bodily processes and maintaining vitality.

Neuropathy Support: ALA has shown promise in supporting individuals with neuropathy, a condition characterized by nerve damage. Some studies suggest that ALA may help alleviate symptoms such as pain and tingling associated with neuropathic conditions. For years, alpha-lipoic acid has been utilized in Germany to address peripheral neuropathy.

Blood Sugar Regulation: Studies indicate that ALA may positively affect your blood sugar levels, making it a subject of interest for those with diabetes. 

It may help improve insulin sensitivity and contribute to better glucose control. One research states that taking alpha-lipoic acid for diabetic neuropathy decreased symptoms compared to a placebo.

Skin Benefits: The antioxidant properties of ALA supplements can help protect and maintain skin health by neutralizing harmful free radicals that can harm the skin and safeguarding it from the detrimental effects of UV rays.

Additionally, by increasing glutathione levels, ALA supplements may diminish the visible signs of aging skin. Due to these benefits, ALA is a frequently used ingredient in many skincare products, as it has the potential to enhance the look of fine lines and wrinkles.

Weight Management: ALA has been shown to reduce the activity of AMPK, a protein that can increase hunger. By suppressing AMPK, ALA may help the body burn more calories while at rest.

Additionally, ALA supplements have been found to help reduce appetite, which can further support weight management efforts.

Types of Alpha Lipoic Acid (ALA)

When it comes to Alpha Lipoic Acid (ALA), there are two primary forms that are commonly discussed:

R-Alpha Lipoic Acid (R-ALA)

R-ALA is the natural form of ALA that is produced by the body. This is a specific and more biologically active form of ALA. R-ALA is known for its enhanced absorption rate, making it easier for the body to utilize. Research suggests that R-ALA may exhibit superior antioxidant properties compared to other forms of ALA.

S-Alpha Lipoic Acid (S-ALA)

The S-ALA form is the mirror image or enantiomer of R-ALA. While R-ALA is considered the natural and more beneficial form, S-ALA also exists. However, studies indicate that S-ALA may not be as readily absorbed or utilized by the body as R-ALA.

Which One To Choose?

When choosing an Alpha Lipoic Acid supplement, it's often recommended to opt for R-ALA due to its better bioavailability and potential enhanced effectiveness. 

R-ALA is more easily absorbed by the body and has been shown to have greater antioxidant activity than S-ALA. As a result, R-ALA is the preferred form of ALA for supplementation and is often used to treat a variety of health conditions.

Best R-Alpha Lipoic Acid (R-ALA) Supplement: R-ALA R-Lipoic Acid by Hi-Tech Pharmaceuticals

R-ALA R-Lipoic Acid by Hi Tech Pharmaceuticals

R-ALA R-Lipoic Acid by Hi-Tech Pharmaceuticals is a natural form of alpha-lipoic acid (ALA) that can be synthesized and safely metabolized by the body. R-ALA is a potent antioxidant that acts as a cofactor of mitochondrial enzymes. It has been shown to be 10 times more effective than ordinary ALA due to its superior bioavailability.

Ordinary ALA has a short half-life and poor absorption due to its poor solubility and instability in the stomach. However, Hi-Tech's R-ALA uses the innovative Cyclosome® formulation, which significantly improves alpha lipoic acid absorption.

How does it work?

Hi-Tech Pharmaceuticals initially stabilizes R-Lipoic Acid (R-LA) by forming a complex with Cyclodextrin (CD). This process has been demonstrated to significantly increase plasma levels, with the area under the plasma concentration-time curve reaching 2.5 times higher than that achieved after the oral administration of non-complexed R-LA.

Following this, this dietary supplement encapsulates R-alpha-lipoic acid within a specially engineered phospholipid bubble known as a liposome. This advanced delivery system results in a 2.8-fold increase in absorption and effectively overcomes digestive challenges, facilitating the direct transportation of R-LA into the body's cells where it is most needed. 

With this meticulous approach, Hi-Tech Pharmaceuticals ensures that you receive the most effective R-Lipoic Acid available on the market.

Key Benefits of R-ALA R-Lipoic Acid by Hi-Tech Pharmaceuticals

  • It works as anti-oxidant support.
  • It reduces oxidative stress.
  • It prevents age-related damage.
  • It promotes glucose metabolism for optimal blood sugar balance.
  • It may protect your nerve tissues against damage.
  • It helps in the detoxification process.
  • It has anti-inflammatory benefits.

Ingredients of Hi-Tech Pharma R-ALA?

  • R-Lipoic Acid

Other Ingredients: Microcrystalline Cellulose, Phosphatidylcholine 75%, Hydroxypropyl Beta Cyclodextrin (HPBCD), Sodium Caprate, Stearate Acid, and Silica.

How to Use Hi-Tech Pharma R-ALA?

Take one tablet daily, preferably with meals.

FAQs: R-ALA (R-alpha lipoic acid)

Q: What is R-ALA, and how does it differ from ordinary ALA?

A: R-ALA, or R-alpha lipoic acid, is a natural and more biologically active form of alpha-lipoic acid. It differs from ordinary ALA in its enhanced absorption rate and greater antioxidant activity.

Q: Can R-ALA Be Used Alongside Other Dietary Supplements?

A: R-ALA can generally be taken alongside other dietary supplements; however, it is always recommended to check with a healthcare expert before adding any new supplement to your routine.

Q: What is the best R-ALA supplement available in the market?

A: The top-rated R-ALA supplement is "R-ALA R-Lipoic Acid by Hi-Tech Pharmaceuticals." This natural form of alpha-lipoic acid is synthesized and safely metabolized by the body.

Q: How much R-ALA is present in the supplement "R-ALA R-Lipoic Acid by Hi-Tech Pharmaceuticals"?

A: The supplement contains 250 mg of R-ALA.


In conclusion, R-Alpha Lipoic Acid (R-ALA) is a powerful antioxidant that offers numerous potential benefits for overall health and well-being. This article explored R-ALA, a powerful antioxidant that might help your body fight to age and stay healthy. It can boost energy, protect nerves, and even help with blood sugar control.

While various supplements are available, Hi-Tech Pharmaceuticals' R-ALA R-Lipoic Acid supplement stands out due to its use of Cyclosome® technology, which enhances absorption and bioavailability.

When choosing an R-ALA supplement, it is essential to look for R-ALA specifically, rather than S-ALA, and to consult with a healthcare professional before beginning any new supplement regimen.


Written and Sponsored by Leonard Shemtob

Leonard Shemtob is President of Strong Supplements. Leonard has been in the supplement space for over 20 years, specializing in fitness supplements and nutrition. Leonard appears on many podcasts, written over 100 articles about supplements and has studied nutrition, supplementation and bodybuilding. 

Leonard's articles have been published in many top publications around the web. Leonard enjoys weight training, playing basketball and yoga, and also enjoys hiking. In his free time he studies and works on improving himself. For more detailed information, visit his official blog.