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​5 Best Supplements for Weight Loss and Muscle Gain [Updated List 2024]

​5 Best Supplements for Weight Loss and Muscle Gain [Updated List 2024]

Posted by Leonard Shemtob on Feb 29, 2024

Achieving the dual goals of weight loss and muscle gain can feel like a double-edged sword. You want to shed unwanted fat while simultaneously building lean muscle mass, which can be a complex endeavor. 

Luckily, certain supplements, when combined with a healthy diet and exercise plan, can provide valuable support on your fitness journey.

This article delves into 5 of the most effective supplements currently available in 2024, exploring their individual benefits and how they can contribute to your weight loss and muscle-building goals.

Whether you are looking to shed those extra pounds or sculpt your muscles, this guide will steer you towards the best supplements tailored for your journey to a stronger, leaner you.

So, let's explore these potential allies on your path to achieving your fitness aspirations!

[Related Article] Muscle Building Supplements - The Ultimate Resource

Short Summary

Latest Recommendations: Explore our updated list of the top 5 supplements for weight loss and muscle gain in 2024.

Key Ingredients Unveiled: Gain insights into the essential components that make these supplements effective for weight loss and muscle building.

Effective Fitness Tools: Discover powerful and proven supplements formulated to assist you in achieving your fitness goals.

From Weight Loss to Muscle Sculpting: Learn how these supplements contribute to shedding pounds while promoting lean muscle development.

Benefits breakdown: Discover the unique ways each supplement can contribute to your weight loss and muscle-building goals.

Ready to Start? Discover the ultimate supplement to kickstart your fitness journey: True Shred by Hard Rock Supplements, our top recommendation for weight loss and muscle building.

5 Best Supplements for Weight Loss And Muscle Gain Reviewed

  1. True Shred by Hard Rock Supplements – Best Overall + Top Choice
  2. AlphaRip by Olympus Labs – Best For Muscle Growth + Fat Loss + Body Recomposition
  3. AlphaBuild by Olympus Labs – Best For Muscle Building + Burning Fat
  4. The Muscle Sculptor by Vital Alchemy – Fat Burner + Appetite Suppressant + Give Men and Women A Rock Hard Well Defined Physique.
  5. AlphaDefy by Olympus Labs – Best For Fat Loss + Endurance + Muscle Regeneration

1- True Shred by Hard Rock Supplements

True Shred by Hard Rock Supplements

True Shred is a cutting-edge supplement designed to help you achieve a lean, hard, and chiseled physique. It is the first-ever hybrid cutting agent that combines natural anabolics and hormone enhancers without prohormones. 

True Shred supports muscle hardening, growth, testosterone, and growth hormone, as well as metabolism boosters. With True Shred, you can get everything you need to get shredded in one bottle, making it the perfect addition to your cutting cycle. Experience the new breed of cutting agents with True Shred.

Key Ingredients of True Shred

7-Keto DHEA is a natural substance similar to DHEA, a hormone in your body. Unlike DHEA, it doesn't turn into other hormones, so you get the benefits without side effects. It helps boost your metabolism, which burns more calories and fat. 

As you get older, you make less 7-Keto DHEA, so your metabolism slows down. Supplements like TrueShred contain 7-Keto DHEA to help you rev up your metabolism and weight loss.

Colostrum: Studies indicate that supplementing with colostrum enhances both endurance and strength performance. Packed with growth factors, colostrum aids in the development of lean muscle. 

It accelerates protein synthesis, promoting lean muscle mass without increasing stored fat. Colostrum further enhances nutrient assimilation, resulting in elevated energy levels and improved overall performance.

Bulbine Natalensis boosts testicular cholesterol levels, which are essential for testosterone production. Research indicates a significant 347% increase in testosterone due to the effect of bulbines on this process.

Chinese Smilax (Laxogenin) is a plant extract believed to help your body build muscle by increasing protein synthesis and reducing muscle breakdown. It may also improve strength, endurance, and recovery and even help control stress hormones.

L-norvaline is a form of L-valine that positively affects nitric oxide circulation and production, enhancing nutrient delivery to muscles during and after workouts.

T2: T2 is a synthetic thyroid hormone that functions like T3 but only burns fat without damaging muscle. It converts slow-twitch fibers to fast-twitch fibers, enabling endurance fibers to convert to strength fibers. This helps you become stronger while shredding fat.

Androsta-3, 5-diene-7, 17-dione: Androsta-3,5-diene-7,17-dione is a natural compound derived from DHEA known as an "aromatase inhibitor." By binding to the aromatase enzyme, it prevents the conversion of testosterone into estrogen, leading to higher testosterone levels and reduced estrogen production. 

This ingredient also helps lower cortisol levels, reducing muscle breakdown and fat accumulation. It enhances muscle hardness, reduces body fat, and minimizes water retention when used independently.

Key Benefits of True Shred

  • It increases muscle hardness.
  • It boosts lean muscle.
  • It improves strength.
  • It helps reduce body fat.
  • It enhances vascularity.
  • It helps boost testosterone levels.
  • It supports your sex drive.
  • It increases metabolism.
  • It reduces estrogen.
  • It promotes growth hormones.
  • It improves endurance.
  • It increases protein synthesis.

Customer Reviews: True Shred

5-stars.pngTrue shread

“I had noticed strength gains starting around 2.5week mark.i also leaned out. I will definitely take this again.”

-Matt I.


“Product is awesome. Works as described. I feel great and have noticed massive gains, and my stomach is considerably smaller/flatter just after 2 weeks of use. Excited to see where I’ll be at the end of this cycle. Will definitely be buying again!”


5-stars.pngMean machine

“This product is off the charts I've been using it for 4 years now off and on cycling but true effects and hard work”


2- AlphaRip by Olympus Labs

AlphaRip by Olympus Labs

AlphaRip is an all-encompassing formula crafted to promote muscle growth and fat loss through various potent pathways. This includes inhibiting the muscle-limiting factor Myostatin, enhancing mitochondrial biogenesis for increased energy production, improving exercise performance, boosting insulin sensitivity, and amplifying crucial beneficial pathways in the body.

By utilizing liquid gel cap technology, Olympus Labs ensures full clinical doses of each ingredient in its purest and most potent form. Say goodbye to plateaus and unlock the factors limiting your muscle gain and fat loss potential with ALPHA RIP!

Key Ingredients of AlphaRip

Ursolic Acid PhytoFUSETM: Olympus is thrilled to introduce Ursolic Acid PhytoFUSETM, a groundbreaking version of a renowned ingredient that previously faced challenges with oral bioavailability. This enhanced form of Ursolic Acid overcomes bioavailability issues, offering significant benefits for muscle building and fat loss. 

With its revolutionary formulation, Ursolic Acid PhytoFUSETM delivers potent effects, unlocking a new level of effectiveness in promoting muscle growth and aiding in fat loss.

RipFACTOR®: The next addition is RipFACTOR®, a clinically studied concentrated herbal formula known for accelerating muscle growth. 

Scientific studies in humans have shown that RipFACTOR® supplementation can enhance strength, endurance, and muscle mass, yielding significant results within just 14 days.

α-Cedren: The formula also includes the innovative ingredient α-Cedrene, making waves in the industry with its unique mechanism of action. α-Cedrene acts as a potent Olfactory receptor (ORs) agonist, triggering significant cAMP increases in targeted areas like muscle and fat cells. 

Included at an effective dosage, it strongly promotes skeletal muscle mass and strength by maximizing muscle protein synthesis while also serving as a potent anti-catabolic and lipotropic agent.

Key Benefits of AlphaRip

  • It helps in your body recomposition.
  • It helps enhance ATP production.
  • It supports muscle protein synthesis.
  • It enhances vascularity.
  • It increases anabolic signaling.
  • It supports your lean muscle growth.
  • It boosts insulin sensitivity.
  • It boosts fat oxidation.
  • It promotes lipolysis.
  • It enhances your overall exercise performance.
  • It promotes healthy levels of anabolic hormones.
  • It supports strength output.
  • It accelerates your recovery.

Customer Reviews: AlphaRip


“Almost complete with first bottle I am loving it so far. Female trying to build or maintain in her 40's seems to be helping. Will continue to use working on changing my composition.”

-Sharon W.


“This supplement is great, at sixty eight years old, I feel and look stronger, than I have in years. This is my first bottle and won’t be my last. I feel, I have increased in my muscles size and shape. Keep up the great work.”

-Robert R.

5-stars.pngPumps, Fullness, and Fat Loss

“I have noticed an increase in heat as well as better pumps and fullness. Also have noticed some leaning out without a perfect diet. I can confidently say it helps you lean out with everything else being equal and that alone makes it worth it to me”

-Marty K.

3- AlphaBuild by Olympus Labs

AlphaBuild by Olympus Labs

ALPHABUILD is crafted to break through the body's limitations, significantly boosting muscle-building potential and simultaneously enhancing fat-burning capabilities!

This powerhouse formula targets fat loss and muscle growth through innovative pathways. It inhibits the muscle-limiting factor Myostatin, boosts mitochondrial biogenesis and output, enhances energy production and exercise performance, increases insulin sensitivity, and amplifies the key anabolic/thermogenic signaling molecule cAMP.

In simpler terms, ALPHABUILD's revolutionary formula provides new avenues for muscle growth, increased strength, vascularity, and efficient fat burning.

Key Ingredients of AlphaBuild

Epicatechin PhytoFUSE: It is a flavanol found in cocoa seeds and green tea and is known for its multifaceted effects on the body. It has been shown to potentially act as a myostatin inhibitor, which is beneficial for muscle growth. Research indicates that it increases follistatin, a protein that inhibits myostatin, by 2.5 times. 

Epicatechin also enhances mitochondrial biogenesis, improving fatigue, increasing resting energy expenditure, and improving exercise capacity. It possesses potent anti-inflammatory, antioxidant, and vasodilatory properties, improving cardiovascular, liver, and kidney health.

α-Ionone: The formula also includes α-Ionone, a potent agonist of Olfactory Receptors (ORs), triggering significant increases in cAMP, especially in muscle and fat cells. This unique mechanism of action enhances muscle and fat cell function, promoting muscle growth and fat loss.

Abscisic Acid: The next addition is Abscisic Acid, a less-known compound in the supplement industry. Don't be misled, though – it's extensively studied in humans and has shown significant benefits in improving glucose disposal, boosting insulin sensitivity, and enhancing the activity of thermogenic brown fat.

Chromium Picolinate is an essential mineral known for regulating insulin in the body by enhancing the signaling of insulin receptors through a protein called Chromodulin. When this protein is impaired, insulin's function is significantly affected. In ALPHABUILD, Chromium Picolinate is included to complement other ingredients that enhance insulin sensitivity.

Key Benefits of AlphaBuild

  • It boosts Follistatin (Myostatin Inhibiting Molecule)
  • It enhances ATP production.
  • It increases muscle protein synthesis.
  • It supports vascularity.
  • It helps you build new muscle tissue.
  • It boosts anabolic signaling.
  • It improves lean muscle growth.
  • It increases insulin sensitivity.
  • It improves insulin sensitivity.
  • It increases fat oxidation and lipolysis.
  • It improves your overall performance.
  • It promotes healthy levels of anabolic hormones.
  • It boosts strength output.
  • It increases myogenesis.
  • It speeds up muscle recovery.

Customer Reviews: AlphaBuild

5-stars.pngA truly great product

“One of the best aspects of this supplement is the pump/fullness you feel almost constantly. Even without a pre workout this stands well on its own. Still have around two weeks left and I’m down 3.5 pounds with strength still increasing. If you’re hesitant on buying it just pull the trigger and do it, it’s worth it.”

-Matthew B.

5-stars.pngAlpha build

“Been using for little over a week seem to be working as advertised so fa far very happy with this supplement”

-Al P.

5-stars.pngThermogenic and Muscle Fullness

“Today makes day 5 of dosing so I’d say I’m fully saturated. This is what I have so far for opinions:

Not sure of the intended thermogenic effects but I’m def sweating a lot more for the durations of my sessions.

Increased pump which has a secondary effect of increased feelings of muscle density throughout the day.”

-Thomas U.

4- The Muscle Sculptor by Vital Alchemy

The Muscle Sculptor by Vital Alchemy

The Muscle Sculptor by Vital Alchemy is a dynamic supplement that combines a potent fat burner to boost metabolism, suppress appetite, and reduce body fat, unveiling muscle definition. Additionally, it features a natural anabolic component to support muscle growth. 

This unique blend aims to help you increase muscle mass while shedding excess fat, sculpting your physique effectively.

Experience the FIRST-EVER anti-catabolic fat burner with The Muscle Sculptor! Transform your body by targeting fat loss and muscle growth simultaneously. Enter a zone of muscle mass hardening while triggering intense fat burning to reveal a sculpted physique. 

Benefit from increased energy, enhanced protein synthesis, appetite control, and cortisol management with this innovative formula.

Key Ingredients of The Muscle Sculptor

Epicatechin: Found in green tea and cocoa, Epicatechin is a powerful antioxidant that decreases Myostatin – a factor limiting muscle growth. By reducing Myostatin, Epicatechin promotes muscle development beyond genetic potential.

Yohimbine HCl: Derived from the Pausinystalia Yohimbe plant, Yohimbine HCl activates the body's 'fight or flight' response, raising core temperature. It releases catecholamines, which bind with fat cells, mobilizing them for energy. Yohimbine HCl also targets stubborn fat areas by blocking alpha receptors, aiding faster fat reduction.

Caffeine Anhydrous: A common stimulant in fat burners, caffeine boosts lipolysis, breaking down fat throughout the body. It suppresses appetite, reduces daily calorie intake, and acts as a mild diuretic, helping prevent water retention and weight loss. Caffeine boosts mental alertness and focus by stimulating the central nervous system.

Grains of Paradise (ParadoxineⓇ): Also called Aframomum Melegueta, helps activate fat burning through Brown adipose tissue. It increases energy expenditure and transforms stored white fat into quickly disposable brown fat.

Phosphatidyl Serine: Phosphatidylserine regulates cortisol levels, counteracting the negative effects of high stress-induced cortisol levels. Supplementing with Phosphatidyl Serine is crucial to manage stress by replenishing depleted levels caused by elevated cortisol.

DiCaffeine Malate: This compound combines Caffeine and Malic Acid to create an ionic bonded compound. It optimizes energy levels, stimulates thermogenesis, and enhances mental focus by leveraging the properties of both Caffeine and Malic Acid.

Evodia Rutaecarpa: It aids in reducing the circulating levels of caffeine, creating a smoother feeling.

Citrus Aurantium: This ingredient boosts the calorie-burning process during food digestion.

Celery Seed Extract: Included for its water retention reduction benefits without affecting sodium and potassium balance in the body.

Key Benefits of The Muscle Sculptor

  • It improves lean muscle gain.
  • It prevents muscle catabolism.
  • It increases protein synthesis.
  • It reduces body fat.
  • It increases energy levels.
  • It helps reduce cravings.
  • It enhances metabolism.
  • It speeds up your muscle recovery.
  • It improves your mood.
  • It reduces water weight.
  • It boosts your focus.
  • It increases thermogenesis.
  • It reduces cortisol.
  • It improves your strength.

Customer Reviews: Muscle Sculptor

5-stars.pngOne of my favs for pre-travel fat loss

“This is an amazing product for fat loss, energy and focus. I use it before I head out on vacation or before the summer to get that fine muscle detail to pop.”

-Garrett C.

5-stars.pngThe muscle sculpture

“This is the one must have for me. Not only does it curve my appetite but it makes me mentally focused.”

-Rick S.

5-stars.pngLove this product.

“My go to everytine am trying to cut. I usually stack it with True Shred and i get great results, losing fat and keeping my lean gains.”

-Tunde S.

5- AlphaDefy by Olympus Labs

AlphaDefy by Olympus Labs

AlphaDefy by Olympus Labs is designed to activate several PPAR pathways - PPAR-Alpha, PPAR-Beta, PPAR-Delta, and PPAR-Gamma - crucial for metabolism and muscle growth. It not only triggers these pathways but also boosts energy expenditure significantly by stimulating brown adipose tissue (BAT) and engaging diverse metabolic pathways, unlocking the potential for muscle growth, fat loss, anabolism, and metabolic optimization simultaneously.

Key Ingredients of AlphaDefy

Garcinia Mangostana L. (peel) Extract (1500mg): Derived from mangosteen fruit peel, rich in xanthones like α-mangostin and γ-mangostin. These compounds offer antioxidant properties and aid in lipid metabolism and energy utilization.

MitoBurn™ (L-β-Aminoisobutyric Acid) (500mg): A branded form of L-β-Aminoisobutyric Acid, potentially converting white adipose tissue to brown adipose tissue, enhancing thermogenesis and fat oxidation. Known as an exercise mimetic for cellular-level benefits.

Artemisia Iwayomogi Extract (300mg): Standardized for dibromo-4-methoxyphenyl, sourced from a plant used in Korean medicine. It activates PPAR-Delta, regulating lipid metabolism for increased fat burning and endurance.

Genistein (50mg): A potent isoflavone acting as a PPAR-Beta activator to enhance fatty acid oxidation and muscle growth potential.

Selective Fat Ignition System (25mg): A blend containing Inulin, Chromium Picolinate (Chromax®), and Avocado extract. Chromium Picolinate enhances insulin sensitivity, and Avocado extract supports glucose management and has anti-inflammatory effects.

Key Benefits of AlphaDefy

  • It improves insulin sensitivity.
  • It enhances fat oxidation.
  • It reduces inflammation and oxidative stress.
  • It boosts energy levels and endurance.
  • It helps you lose fat.
  • It improves muscle regeneration.
  • It improves insulin resistance.
  • It promotes muscle performance.

Customer Reviews: AlphaDefy

5-stars.pngIncreasing in the right areas - beta tester

“Muscle preservation in a caloric deficit was the most notable effect for me, personally. Everything tightened up, vascularity increased, and nutrients were shuttled right where they needed to be.”

-Owen Z.

5-stars.pngWorks great -beta tester

“It works as stated. My strength as increased and recovery has been good. All of this while training fasted. It has also helped with nutrient partitioning. My diet hasn’t been the best and I’ve still been able to recomp nicely.”

-Marty K.

5-stars.pngI got leaner!

“Ladies and gentlemen we are 1 week on Alpha Defy and even today at the gym my bros said I got leaner. Guess stuff is working as I didnt made any drastic changes to my daily regime. Still on same calories, still doing cardio and training 6 times per week. So far so good. Alpha Chisel goes in tomorrow! Time to get peeled. Oh and btw - I found a store in Europe that has other skus from Olympus based in Germany. Ordered some older skus but also grabbed new skus. Alpha Rip in particular ?❤️ will post the pic once it will came in ??”

-Richard L.

How We Chose the Best Supplements for Weight Loss And Muscle Gain

Selecting the right weight loss and muscle gain supplements is a crucial decision on the path to achieving fitness goals. Here's a glimpse into the criteria that guided our selection:

Scientific Research and Evidence-Based Approach

Our choices are rooted in scientific research and a commitment to evidence-based solutions. We delved into studies, clinical trials, and scientific literature to understand the effectiveness of each supplement in promoting weight loss and muscle gain.

Ingredient Transparency and Quality

Transparency matters when it comes to supplements. We considered products that clearly disclose their ingredients and their respective dosages. Quality assurance, including third-party testing, played a pivotal role in our selection process to ensure the safety and purity of the supplements.

Expert Consultation

Our team consulted with fitness experts and nutritionists to gain insights into the effectiveness and safety of these supplements in aiding weight loss and muscle growth.

User Reviews and Testimonials

Real-world experiences matter. We took into account user reviews and testimonials to gauge the practical impact of these supplements. Positive feedback and success stories from people who have used these products contributed to their inclusion on our list.

Safety and Side Effects

Safety is paramount. We considered potential side effects and adverse reactions associated with each supplement. Products with a low incidence of side effects and a higher safety profile were favored in our selection.

What to Look for in Best Supplements for Weight Loss And Muscle Gain

When choosing weight loss and muscle-building supplements, it's crucial to consider some key factors to make sure you choose the most effective products for your fitness goals. Here are some important aspects to look for:

Ingredients Matter

Check the ingredient list carefully. Look for crucial components such as metabolism boosters, muscle-building agents, and natural fat burners. Understanding the ingredients will give you insight into how the supplement works and its potential effectiveness.

Check Ingredient Transparency

Look for supplements that clearly list their ingredients and dosages. Transparency is key to ensuring you know exactly what you're putting into your body. Avoid products with vague or proprietary blends.

Consider Scientific Backing

Opt for supplements backed by scientific research. Check for studies and clinical trials supporting the effectiveness of the ingredients.

User Reviews and Experiences

Real-world experiences provide valuable insights. Read user reviews and testimonials to understand how others have responded to the supplement.

Brand Reputation

Consider the reputation of the brand. Reputable brands often have a history of delivering quality products. Look for customer satisfaction ratings, and choose supplements from trustworthy sources.

Third-Party Testing

Look for supplements that undergo third-party testing. This additional layer of scrutiny ensures that the supplement has been independently verified for quality, purity, and adherence to manufacturing standards.

FAQS: Best Supplements for Weight Loss And Muscle Gain

Q: Can I take multiple supplements together for better results?

A: Combining supplements can be beneficial if done carefully and in moderation. However, Some ingredients may interact negatively when taken simultaneously. Consult with a healthcare expert to ensure compatibility and avoid potential complications.

Q: Are weight loss and muscle gain supplements safe to use?

A: Generally, many supplements are safe when used as directed. However, individual reactions may vary. It's crucial to follow recommended dosages and consult with a healthcare expert, especially if you have pre-existing health conditions or are taking other medications.

Q: How do I choose the right supplement for my needs?

A: Consider your fitness goals, health status, and personal preferences. Look for supplements with ingredients aligned with your objectives. Reading user reviews and consulting with a healthcare professional can guide your decision.

Q: How long does it take to see results from these supplements?

A: Results vary depending on individual factors like diet, exercise routine, and metabolism. Typically, noticeable changes may be observed within a few weeks to a few months of consistent use.


In conclusion, our exploration of the "5 Best Supplements for Weight Loss and Muscle Gain" has shed light on valuable tools for achieving fitness goals effectively. 

By combining scientific research, expert insights, user feedback, and safety considerations, we've curated a list of supplements that stand out for their potential to support weight loss and muscle gain journeys.

Whether you're aiming to shed unwanted pounds, sculpt lean muscle, or embark on a comprehensive transformation journey, these supplements provide valuable support along the way. 

Remember to consult with a healthcare specialist and stick to suggested dosages for optimal results and safety.

Cheers to a healthier, stronger you!


Written and Sponsored by Leonard Shemtob

Leonard Shemtob is President of Strong Supplements. Leonard has been in the supplement space for over 20 years, specializing in fitness supplements and nutrition. Leonard appears on many podcasts, written over 100 articles about supplements and has studied nutrition, supplementation and bodybuilding. 

Leonard's articles have been published in many top publications around the web. Leonard enjoys weight training, playing basketball and yoga, and also enjoys hiking. In his free time he studies and works on improving himself. For more detailed information, visit his official blog.