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​The Ultimate Guide to Estrogen Blockers for Men in 2024

​The Ultimate Guide to Estrogen Blockers for Men in 2024

Posted by Leonard Shemtob on Jan 18, 2024

The Ultimate Guide to Estrogen Blockers for Men in 2024

Men's health is critical to overall wellbeing and longevity. Estrogen, traditionally associated with female reproductive organs, plays an important role in male biology as well. High levels of estrogen have been linked to a number of conditions such as the development of breast tissue, infertility, and loss of libido.

To address this, many men are turning to estrogen blockers—pharmaceutical and natural agents that help reduce the biological effects of estrogen. In this Ultimate Guide to Estrogen Blockers for Men in 2024, we look at the causes and implications of high estrogen, the various types of blockers, their benefits and risks, where and how to obtain them, as well as dietary and lifestyle changes that can help balance hormones.

Short Summary

What is Estrogen and How Does it Affect Men?

fitness, athlete, workout

Estrogen is a hormone that is important for male health, with roles in bone health, brain function, libido, sexual performance, and reproductive capacity. In males, it is essential to maintain the correct balance between estrogen and other hormones, particularly testosterone.

Elevated estrogen levels in men can cause a range of adverse effects, such as decreased muscle mass and endurance, gynecomastia, fatigue, reduced libido, and weight gain. The underlying causes of elevated estrogen levels in men can include aging, aromatization, dietary deficiencies, stress, and certain medical conditions such as aromatase excess syndrome.

Men may consider having their estrogen levels tested if they are exhibiting signs of elevated estrogen, are anorexic, overweight or obese, or are experiencing chronic stress.

Causes of High Estrogen in Men

Aromatization is the process through which testosterone is converted to estrogen in the body, resulting in elevated estrogen levels in males. Furthermore, dietary choices, such as an excessive amount of unhealthy foods or simply too much food overall, can lead to weight gain. Body fat contains the aromatase enzyme, so the more fat a person has, the more likely their estrogen levels will be elevated.

Other factors that may contribute to elevated estrogen levels in men include aging, aromatization, inadequate nutrition, and stress. Men with high estrogen levels may experience infertility, erectile dysfunction, and other associated symptoms.

Gynecomastia, or Gyno and Estrogen

Gynecomastia, or "gyno," is the enlargement of breast tissue in men, often resulting from an imbalance of the hormones estrogen and testosterone. Anabolic steroids, which are synthetic derivatives of the male hormone testosterone, can cause gyno and high estrogen levels in men when used improperly. Thus people who run cycles of anabolics can have high estrogen levels that can lead to gyno.

Here's how this can occur:

  1. Aromatization: Anabolics can be converted to estrogen through a process called aromatization. This occurs when the enzyme aromatase converts testosterone (or other androgens) into estrogen. Some anabolic steroids are more prone to aromatization than others, leading to higher levels of estrogen in the body. This increase in estrogen can cause gyno and other estrogen-related side effects.
  2. Suppression of natural testosterone production: Some Anabolics can suppress the body's natural production of testosterone. When testosterone levels decrease, the ratio of estrogen to testosterone can become imbalanced, leading to an excess of estrogen. This hormonal imbalance can result in gynecomastia and other side effects.
  3. Prolactin and progesterone: Running a cycle can also increase the levels of other hormones, such as prolactin and progesterone, which can contribute to gynecomastia. These hormones can stimulate breast tissue growth and exacerbate the development of gyno.

Estrogen Blockers for Men

vitamins, pills, pharmacy

Estrogen blockers are supplements designed to regulate estrogen levels in the male body. They work by inhibiting aromatase and may also act on the estrogen receptors, thereby reducing the amount of estrogen in the body and helping to balance hormone levels. Estrogen blockers are utilized to reduce the levels of estrogen in the body, typically for the treatment of conditions such as breast cancer and infertility.

The potential advantages of utilizing estrogen blockers include reducing the risk of gynecomastia, improving mood, focus, and concentration, and increasing physical performance. However, there are also some drawbacks to consider, such as potential side effects and the possibility of disrupting the body's natural hormone balance.

Some Estrogen blockers require a prescription from a healthcare provider to be obtained. This can then be used to purchase the medication. Natural estrogen blockers can be found over the counter. It is vital, however, to speak to a healthcare professional before taking them to ensure that they are safe for you.

It is recommended to speak with a doctor to receive their advice on what treatment may be most effective.

Pharmaceutical Estrogen Blockers

Pharmaceutical estrogen blockers are utilized to reduce the levels of estrogen in the body, typically for the treatment of conditions such as breast cancer and infertility. The two primary pharmaceutical agents used to block estrogen production are aromatase inhibitors and selective estrogen receptor modulators (SERMs).

Aromatase inhibitors work by inhibiting the enzyme aromatase, which is responsible for converting testosterone into estrogen. SERMs, on the other hand, bind to estrogen receptors in the body, thus preventing estrogen from binding to those receptors.

Pharmaceutical estrogen blockers can sometimes cause undesirable side effects such as hot flashes, headaches, mood changes and joint pain. It is important to be aware of the possible risks that come with taking these medications. Additionally, there is a potential increased risk of certain conditions, including blood clots and endometrial cancer.

Early studies suggest that anastrozole and letrozole may be beneficial in treating male infertility. These medications work by decreasing estrogen levels, which can potentially lead to an increase in testosterone production and improved sperm count and motility.

Natural Estrogen Blockers

Natural estrogen blockers are compounds found in plants and other natural sources that can assist in the regulation of hormone levels in the body. These compounds can provide a range of potential benefits, such as improved hormone balance and reduced risk of certain health conditions.

Certain natural substances have been identified as effective estrogen blockers, including wild nettle root, maca, chrysin, grape seed extract, and DIM, which is found in cruciferous vegetables such as broccoli, cabbage, cauliflower, and kale.

Though the scientific evidence for the efficacy of natural estrogen blockers is limited, some individuals may find that using them can help to regulate their hormone levels. It is essential to consult a physician before attempting natural estrogen blockers, as they often have limited testing and data regarding their efficacy, or may even be untested in a clinical environment.

You can view the TOP 5 Estrogen blockers for men Ranked here!

What do estrogen blockers do for men

boxing, sport, sports

Estrogen blockers are pharmaceuticals that inhibit the body's estrogen production or impede estrogen from attaching to receptors. The objective of estrogen blockers is to help adjust hormone levels in men, as an excess of estrogen or low testosterone can have adverse effects. Estrogen blockers have been found to be effective in raising testosterone levels and reversing infertility in men and are also used in the treatment of breast cancer.

Estrogen blockers prevent the production of estrogen in the body. Consequently, testosterone levels will be increased. It is essential for men to seek medical supervision prior to taking estrogen blockers, as they can have adverse side effects and may cause hormone levels to decrease to an unhealthy degree.

Avoiding Environmental Estrogens

sunset, boy, open arms

Environmental estrogens are substances found in the environment, including synthetic hormones found in animal meat, plastic food wraps and containers, and toiletries containing parabens. To reduce exposure to environmental estrogens, men should filter their drinking water, opt for organic and locally-grown foods, abstain from using pesticides and herbicides, switch to glass or stainless steel containers instead of plastic, and select skincare and household products with naturally derived ingredients.

Certain meats from animals that have been administered synthetic hormones, plastic food wraps and containers, and toiletries containing parabens are all potential sources of environmental estrogens. To reduce exposure to these potential sources of estrogen, it is suggested to opt for organic and locally-grown foods, avoid using plastics whenever possible, and be mindful of the ingredients in skincare and household products.

Additionally, it is important to maintain a healthy weight and limit alcohol consumption to reduce exposure to environmental estrogens.

Nutritional Changes

salad, fruit, berry

High fat diets can contribute to increased estrogen levels due to the presence of an enzyme called aromatase in fat cells, which converts testosterone into estrogen. Cruciferous vegetables contain a compound known as indole-3-carbinol, which assists in the regulation of estrogen levels by converting stronger forms of estrogen into weaker forms. This can result in an increase in testosterone levels.

Reducing alcohol intake can have a positive effect on the regulation of estrogen and an increase in testosterone levels. This is due to the fact that alcohol can cause damage to the liver, which is responsible for metabolizing estrogen. By reducing alcohol intake, the liver can function more efficiently and help regulate estrogen levels, thus leading to an increase in testosterone levels.

Making changes to your diet can be a great way to help restore a healthy balance of hormones, as well as help with weight gain, bone density, and liver and kidney function. Eating a balanced diet, filled with natural alternatives to processed foods, can help reduce body fat and regulate hormonal balance. Studies have shown that low bone mineral density, and excess body fat, can be linked to high levels of estrogen. Additionally, reducing alcohol intake and limiting processed foods can help to increase weight loss and improve blood tests.

It’s important to note that alcohol interferes with the natural balance of hormones, so limiting alcohol intake is vital for regulating estrogen levels.

Pros and Cons of Estrogen Blockers

pros, and, cons

Estrogen blockers are a class of pharmaceuticals that work to inhibit the conversion of testosterone to estrogen. They are used for therapeutic purposes in cases like gynecomastia, infertility, and low testosterone levels. This treatment can prove to be beneficial for those suffering from such conditions. There are both advantages and disadvantages to utilizing estrogen blockers, and it is important to consider and understand both before deciding to use them.

When it comes to the advantages of using estrogen blockers, they can help raise testosterone levels, reverse infertility, and manage conditions associated with elevated estrogen levels such as gynecomastia. Estrogen blockers have also been proven to be an effective treatment for certain types of breast cancer. In addition, they have been known to be beneficial in restoring healthy estrogen levels.

On the other hand, there are potential adverse effects associated with utilizing estrogen blockers. These range from decreased bone density to hot flashes and a decrease in libido. Other possible side effects may include fatigue, depression, and erectile dysfunction. Long-term use of estrogen blockers may increase the likelihood of developing osteoporosis and cardiovascular disease. Therefore, it is important to consider both the advantages and disadvantages of using estrogen blockers before deciding to utilize them.

Estrogen Blockers GNC

GNC is a leading retailer of health and nutrition-related products, offering a wide selection of quality items. Among these, GNC provides natural estrogen blockers for men, however they formulas that these supplements possess are inferior and out of date compared to what's available on the market today. For example Eradicate by Blackstone Labs ingredient profile contains ingredients like arimstane that work far more efficiently than most if not all of GNC's estrogens blocker for men.

Buy Estrogen Blockers

Estrogen blockers can be procured either through an online source or via a doctor's prescription. Buying estrogen blockers online can provide greater convenience and may offer a broader range of options, however, there is an increased likelihood of receiving counterfeit or ineffective products. Notable online retailer and supplement companies that provide estrogen blockers include

Furthermore StrongSupplementShop carries the best and strongest Estrogen blocker supplements for men

Their Top Picks Include:

Terminate By Hard Rock Supplements

Terminate by Hard Rock Supplements

Terminate contains compounds with a proven track record and the formula is dosed to the proper levels. Terminate has proven itself over and over again with great feedback and a great price. Effectiveness, formula, reviews and value make it the top choice by far. Read more by clicking on the link above.

Eradicate by Blackstone Labs

Blackstone Labs Eradicate

Eradicate by BSL has been one of the most popular estrogen blockers for many years. Eradicate contains a suicide aromatase inhibitor that stops estrogen dead in its tracks. Great Reviews and well thought out and effective formulation bring it in as another top pick for estrogen blocker for men.

Consulting a doctor prior to taking estrogen blockers is essential as they can provide guidance on potential side effects and interactions with other medications. It is important to remember that taking estrogen blockers without consulting a doctor can result in a variety of dangerous side effects, including but not limited to an increase in blood clots, a decrease in estrogen production, and an increase in testosterone levels.

Therefore, it is essential to speak with a medical professional to ensure safety and proper dosage when taking estrogen blockers.


SERMs are a class of synthetic hormonal medications that can both imitate and inhibit the effects of estrogen in the body. They are capable of binding to estrogen receptors in the body, thereby blocking or activating them depending on the tissue type.

This allows for a targeted approach to modulating estrogen's effects in specific tissues. SERMs are frequently prescribed to address breast cancer, osteoporosis, and postmenopausal symptoms. Additionally, they may be employed off-label to treat a range of conditions associated with low testosterone, including infertility, low sperm count, gynecomastia, and osteoporosis.

SERMs are an effective means of blocking estrogen in males. They can also be used off-label to address conditions related to low testosterone, such as infertility, low sperm count, gynecomastia and osteoporosis.


Estrogen blockers can be a beneficial tool for men seeking to restore balance to their hormones and improve their overall health. Estrogen blockers are a type of medication or supplement that works to reduce the amount of estrogen in the body, allowing for an increase in testosterone levels. Consulting with a healthcare provider prior to utilizing estrogen blockers is essential to ensure safety and effectiveness, as well as to determine the best treatment option.

In addition to medication or supplements, lifestyle changes such as avoiding environmental estrogens, making nutritional changes, and taking natural estrogen blockers can also help reduce the amount of estrogen in the body. A blood test and monitoring of kidney function may also be necessary in order to assess the efficacy of estrogen blockers.

Ultimately, estrogen blockers can be a valuable tool for men looking to improve their health. However, it is important to consult with a healthcare provider before utilizing them, as they can have potential side effects.


The use of estrogen blockers is an effective way to address health issues related to excess estrogen and low testosterone in men. These products can help restore a healthy balance of hormones, alleviating symptoms like infertility and erectile dysfunction. However, it is important to keep in mind that supplementation with these products should always be done under medical supervision in order to ensure safety and effectiveness.

Additionally, incorporating nutritional and lifestyle changes into one's routine, such as opting for organic and locally-grown foods or avoiding certain plastics, can further aid in restoring balance and improving overall wellbeing. The goal of any treatment plan should be to attain a healthy equilibrium between sex hormones, which will ultimately result in improved physical and mental health.

Frequently Asked Questions

What happens if a man takes estrogen blocker?

Taking an estrogen blocker, such as clomiphene citrate, can lead to a variety of side effects. However, studies suggest that it may be effective in increasing testosterone levels and improving bone mineral density with minimal side effects.

Therefore, it may be a beneficial option for those looking to reduce estrogen levels.

Why should men take estrogen blockers?

Taking estrogen blockers is essential for men who experience a disruption in their hormones due to age-related natural hormone changes or for other reasons, as these blockers can help regulate the balance and may reduce risk or symptoms of diseases associated with hormone imbalances.

Therefore, men should consider taking estrogen blockers to keep their hormone levels in balance.

Do estrogen blockers work men?

Estrogen blockers can be used by men as part of a bioidentical hormone replacement therapy regimen to reduce their levels of estrogen, thereby allowing testosterone levels to increase. Both natural and synthetic blockers may be suitable options for patients, depending on individual needs.

Ultimately, the decision should be made with the help of a medical professional.

Should I take an estrogen blocker with testosterone?

It is best to take an estrogen blocker if you are taking testosterone for enhancing athletic performance or for the therapy of male hypogonadism.

Therefore, it is recommended to take an estrogen blocker with testosterone.

What does estrogen blockers do?

Estrogen blockers are supplements that reduce the amount of estrogen in the body. They work by blocking the action of the enzyme aromatase, which is responsible for producing estrogen in fat tissue. By blocking this enzyme, estrogen levels are reduced.


  1. MedlinePlus: MedlinePlus is a service provided by the National Library of Medicine, offering reliable and up-to-date health information. You can find information on gynecomastia, its causes, and treatments on their website. S
  2. Mayo Clinic: The Mayo Clinic is a respected medical research institution and offers information on various health topics, including anabolic steroids and gynecomastia. Anabolic Steroids: Gynecomastia:
  3. Nieschlag, E., & Vorona, E. (2015). Medical consequences of doping with anabolic androgenic steroids: effects on reproductive functions. European Journal of Endocrinology, 173(2), R47-R58. Source:
  4. Pope, H. G., Wood, R. I., Rogol, A., Nyberg, F., Bowers, L., & Bhasin, S. (2014). Adverse health consequences of performance-enhancing drugs: An Endocrine Society scientific statement. Endocrine Reviews, 35(3), 341-375. Source:

Written and Sponsored by Leonard Shemtob

Leonard Shemtob is President of Strong Supplements. Leonard has been in the supplement space for over 20 years, specializing in fitness supplements and nutrition. Leonard appears on many podcasts, written over 100 articles about supplements and has studied nutrition, supplementation and bodybuilding. 

Leonard's articles have been published in many top publications around the web. Leonard enjoys weight training, playing basketball and yoga, and also enjoys hiking. In his free time he studies and works on improving himself. For more detailed information, visit his official blog.

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