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​The Top 3 Best Anti-Estrogen Supplements

​The Top 3 Best Anti-Estrogen Supplements

Posted by Leonard Shemtob on Jun 26, 2023

The Top 3 Best Anti-Estrogen Supplements

Hormonal balance plays a vital role in overall health and well-being, and one key hormone that requires careful regulation is estrogen. Estrogen, a primary female sex hormone, is also present in males and serves various essential functions in the body. However, when estrogen levels become imbalanced, it results in a range of health problems and discomforts. In such cases, the use of estrogen blocker supplements, also known as anti-estrogen supplements, can be a valuable tool in restoring equilibrium.

Estrogen blockers, as the name suggests, are substances that help counteract the effects of too much estrogen by inhibiting its production or blocking its receptors. These supplements have gained significant attention in recent years as individuals seek natural and effective methods to manage hormonal imbalances. By incorporating specific estrogen blocker supplements into their daily routines, individuals can support their hormonal health and potentially alleviate symptoms associated with excess estrogen.

In this detailed guide, we will delve into the world of estrogen blocker supplements and explore the top contenders in the market. We will examine their mechanisms of action, benefits, and key ingredients and empower you with the knowledge to make informed decisions about which supplements may be most suitable for your needs.

Short Summary

What is Estrogen?

Estrogen is a vital hormone in the reproductive system and various physiological processes in both males and females. It belongs to a group of hormones called the "female sex hormones" but is also present in smaller quantities in males.

Estrogen is primarily produced in the ovaries in females and, to a lesser extent, in the adrenal glands and fat cells. In males, it is produced in the testes and also converted from testosterone via the aromatase enzyme.

Estrogen influences the growth and development of secondary sexual characteristics in females. It also regulates the menstrual cycle, promotes the thickening of the uterine lining, and supports the maturation of eggs in the ovaries.

Beyond reproductive functions, estrogen affects various tissues and organs throughout the body. It plays vital a role in maintaining healthy bones by influencing bone density and calcium absorption. Estrogen also affects cardiovascular health, cognitive function, mood regulation, and skin health.

What Causes Estrogen Levels to Rise?

There are several factors that can cause estrogen levels to rise in the body. Here's a brief explanation:

Hormonal Imbalances: Hormonal imbalances, particularly excess estrogen, can cause estrogen levels to rise. This can occur for various reasons, including fluctuations in other hormones such as progesterone or testosterone.

Obesity: Adipose tissue (fat cells) can produce estrogen. Therefore, higher body fat levels, especially in the abdominal area, can contribute to increased estrogen production and higher estrogen levels.

Medications and Therapies: Certain medications and therapies can elevate estrogen levels. For example, hormone replacement therapy (HRT) or certain types of birth control pills may contain estrogen, increasing circulating estrogen levels.

Environmental Factors: Exposure to environmental chemicals known as endocrine disruptors can interfere with hormone regulation and potentially lead to elevated estrogen levels. These chemicals are found in certain plastics, pesticides, and industrial pollutants.

Certain Medical Conditions: Certain medical conditions, such as polycystic ovary syndrome (PCOS) and certain types of tumors (e.g., ovarian or adrenal tumors), can cause excess estrogen production and result in higher estrogen levels.

Aging: As individuals age, the production and regulation of hormones, including estrogen, can change. In some cases, estrogen levels may increase with age, particularly during perimenopause and menopause.

What is Anti-estrogen?

Anti-estrogen supplements are dietary supplements designed to regulate estrogen levels in the body. They work by either blocking estrogen production or inhibiting its effects on the body's tissues and receptors. These supplements aim to restore hormonal balance and alleviate symptoms associated with estrogen dominance, such as mood swings and bloating.

How Does an Estrogen Blocker Work?

Estrogen blockers that work by inhibiting estrogen production primarily target the enzyme aromatase. Aromatase is responsible for converting androgens, such as testosterone, into estrogen. By inhibiting the activity of aromatase, these blockers can effectively reduce the conversion of androgens into estrogen, leading to lower overall estrogen levels in the body.

Aromatase inhibitors (AIs) are a class of medications commonly used as estrogen blockers to inhibit aromatase activity. They work by binding to the aromatase enzyme, either reversibly or irreversibly, thereby preventing it from converting androgens into estrogen.

Top 3 Anti-estrogen Supplements

1- Terminate by Hard Rock Supplements

Terminate by Hard Rock Supplements

Discover the ultimate solution for terminating estrogen and escalating testosterone with Terminate, proudly brought to you by Hard Rock Supplements! This powerful supplement is designed to deliver various benefits, including increased muscle hardness, estrogen reduction, prolactin reduction, decreased body fat, and a boosted libido.

Terminate's cutting-edge formula stands unrivaled, combining effective ingredients at optimal dosages to provide the most potent estrogen-blocking experience available on the market today.

Terminate is your go-to solution whether you're on a cycle and need to regulate estrogen levels or seek a standalone estrogen blocker and muscle hardener.

Key ingredients:

Trans-Resveratrol 50%: This natural extract, when consumed in high doses, offers numerous benefits, such as blocking estrogen, maintaining estrogen balance, promoting anti-aging effects, regulating the immune system, enhancing cellular energy, and providing an antioxidant defense.

Androst: Derived from DHEA, Androst is a natural compound recognized for its role as an "aromatase inhibitor." Aromatase is an enzyme that is responsible for converting testosterone into estrogen. By inhibiting aromatase, Androst binds to the enzyme, preventing the conversion of testosterone to estrogen. This not only prevents excess estrogen production but also leads to elevated testosterone levels, as the inhibition of estrogen conversion maintains higher levels of testosterone in the body.

Furthermore, Androst helps reduce cortisol, a hormone that promotes muscle breakdown and fat accumulation. As a standalone ingredient, Androst promotes enhanced muscle definition while reducing body fat and water retention.

Boron: A vital mineral necessary for optimal bone development, Boron has also been shown for the ability to lower SHBG levels, leading to elevated testosterone levels.

Boron Glycinate: This ingredient serves multiple purposes, contributing to the development of strong bones, supporting muscle growth, and, importantly, enhancing testosterone levels.

Zinc: In a study examining the effects of zinc supplementation, it was observed that men who took zinc supplements experienced higher levels of free testosterone in their bodies.

LongJack has been suggested to impact SHBG levels based on clinical studies. Additionally, it has been found to possess anti-aromatase properties similar to Formestane, leading to a decrease in estrogen and an increase in testosterone levels.

Shilajit: A biomass abundant in essential nutrients, minerals, humic acids, and fulvic acids, Shilajit has been revered for centuries as an excellent source of energy and nutrition for the human body. Recent studies have demonstrated its potential to promote increased secretion and stimulation of testosterone.

Key benefits:

  • It helps increase muscle hardness
  • It helps reduce estrogen level
  • It helps boost libido
  • It helps boost testosterone level
  • It improves vascularity
  • It enhances strength
  • It helps reduce body fat
  • It helps reduce water retention
  • It helps reduce cortisol level

Customer reviews about the product:

5-stars.pngThis products work

“Terminate does exactly what it says it will do. After 1 week use use I noticed a big difference in my energy levels and my muscle fullness was getting better. I would highly recommend this product if you are looking to lose bodyfat and have your muscles more full and hard.”

-Frank C.

5-stars.pngLove it

“I love the product. It works as it should. I'll take it with DAA Max. this is the 3rd time I have ordered it. I am ***** all the time and the lady is happy about it? try it and you won't regret it”



“Hard rock again, harder muscle, increased libido, and improved mood! And all this while losing fat! Amazing product”


2- Eradicate by Blackstone Labs

Eradicate by Blackstone Labs

Are you tired of not achieving the chiseled physique you desire? One factor that may be holding you back is estrogen. However, with Eradicate by Blackstone Labs, you can take control of estrogen and unveil the lean, dry, and hard muscles that will turn heads both inside and outside the gym.

While it's normal for men to have estrogen, its presence can lead to water retention, inhibiting muscle definition. But that's not all. Increased estrogen levels can cause bloating, especially in the abdominal area, making it challenging to achieve a six-pack. Moreover, it reduces testosterone production, making it difficult to build muscle mass.

Eradicate by Blackstone Labs is a powerful solution designed to put you back in control. Its key ingredient, Arimistane, is a potent estrogen reducer known for its ability to eliminate estrogen.

Let me explain how it works. Estrogen is produced by an enzyme called Aromatase, which converts testosterone into estrogen. Arimistane, also known as a "Suicide Aromatase Inhibitor," binds to this enzyme, preventing the conversion of testosterone into estrogen. Consequently, your testosterone levels increase, boosting your libido, enhancing muscle hardness, and reducing body fat and water retention.

If you're currently undergoing a hardcore anabolic cycle, managing estrogen is crucial to prevent side effects like Gyno. Eradicate the possibility of such complications by incorporating Eradicate into your regimen.

Its key ingredient includes:

Arimistane, a natural compound and metabolite of DHEA, possesses remarkable properties as an "aromatase inhibitor." This means that it inhibits the activity of the aromatase enzyme works by converting testosterone into estrogen. Arimistane effectively hinders the conversion process by binding to the aromatase enzyme, preventing excess estrogen production. As a result, your testosterone levels remain elevated since they are not being converted into estrogen.

But the benefits continue beyond there. Arimistane also plays a role in reducing cortisol, a hormone that promotes muscle breakdown and fat accumulation. By helping to decrease cortisol levels, Arimistane prevents muscle catabolism and aids in reducing body fat and water retention. Moreover, as a standalone ingredient, Arimistane contributes to increased muscle hardness.

Key benefits:

  • It promotes increased muscle hardness, giving your physique a more defined and sculpted appearance
  • By supporting improved blood flow and circulation, this supplement can help enhance vascularity, allowing your veins to become more prominent and visually striking.
  • It aids in stimulating the production of luteinizing hormone, which plays a critical role in testosterone production.
  • Cortisol, a stress hormone, can negatively impact muscle tissue and promote fat accumulation. Arimistane assists in reducing cortisol levels.
  • It helps enhance libido.
  • It supports increased testosterone levels.

Customer reviews about the product:

5-stars.pngThis E blocker works

“This stuff works. Took this at the end of a cycle. I knew it was working because the next morning after taking this, I woke up with morning wood.”

-Anthony S.


“After my second cycle I start to develop a little gyno and puffiness in my nipples got worst by the 3-rd week. I stop the cycle right away and I start running Eradicate and Aroma X for the next 2-3 weeks straight. I swear my nipples went back in and I am so happy because I almost start worrying that i will need surgery. GREAT PRODUCT ! It DOES GET RID OF THE ESTROGEN IN YOUR BODY AND MAKE YOU KEEP YOUR GAINS. Hope they will never take it down.”


5-stars.pngDelivers as promised.

“Used this product as a pct after a mild pro-hormone cycle for the purpose of drying out the extra water retention as the cycle I ran consisted of two wet compounds. Took about a week of use to get the full effect and I couldn't be happier it definitely helped me regulate my hormones and reduced some slight gyno and took me from being bloated with water to looking dry .”


3- Estrogenex 2nd Generation by Hi-Tech Pharmaceuticals

Estrogenex 2nd Generation by Hi Tech Pharmaceuticals

Are you frustrated that your hard-earned gains are not visible? Unleash them from hiding and take control of estrogen with Estrogenex 2nd Generation!

Estrogenex is specifically designed to decrease estrogen levels, triggering a chain reaction that enhances muscle definition. By reducing body fat and shedding water weight, Estrogenex helps reveal your chiseled physique while promoting improved vascularity and muscle hardness.

But that's not all—Estrogenex goes a step further by supporting increases in testosterone levels and boosting your libido, providing additional benefits to enhance your overall performance and well-being.

Key ingredients:

Chrysin: is a flavonoid compound, which has gained popularity in the bodybuilding community for its ability to elevate testosterone levels while reducing estrogen.

Indole-3-Carbinol is one of the most researched nutraceuticals on the market, mainly widely studied for its anti-breast cancer properties. It acts as a negative regulator of estrogen and can modify estrogen metabolism.

Eurycoma Longifolia: widely known as Tongkat Ali, this compound promotes heightened sexual desire through various mechanisms, including its effects on free testosterone, sex hormone-binding globulin (SHBG), and aromatase activity. SHBG is a glycoprotein that binds to free testosterone, reducing its availability.

Key benefits:

  • It helps improve libido
  • It reduces estrogen
  • It helps increases testosterone
  • It helps reduce body fat
  • It helps decreases water retention
  • It improves vascularity
  • It helps increase muscle hardness muscle mass

Customer reviews about the product:

5-stars.pngAbsolutely awesome!!

“Alright, so ******* me, I took a super drol clone without really knowing it. Granted, I knew I needed a pct, but I didn't know what serms were. I used this as my pct, and only this. I had begun getting puffy nipples towards the end of the cycle, this got rid of everything, and I kept all gains. Considering how irresponsible I was about it, and how well this stuff worked says something!”



“simply works man, I am estrogen sensitive and ostarine was starting to give me *******, jumped on this stuff and reversed me in days. Very impressed.”


5-stars.pngBest anti-aromatase on the market!

“I have used this product for ALL of the cycles I run with a pro-hormone. It was recommended by a friend so I gave it a shot. This formulation uses the 5-a Androstan , which , if you look it up, is basically a pro-hormone itself that ONLY stops aromatization. I experienced tightness of my physique, and overall better endurance and stamina while taking this product. I'd recommend this over ANY anti-aromatase product out there. I run it DURING my cycle but it could probably work as a PCT as well!”


You can shop all the best Estrogen Blockers Here

Frequently Asked Questions (FAQs) about Best Anti-estrogen

Q: What are estrogen blocker supplements, and how do they work?

A: Estrogen blocker or anti estrogen supplements are dietary supplements designed to regulate estrogen levels in the body. They contain natural ingredients that target the pathways involved in estrogen production or interfere with estrogen receptor activity.

Natural Estrogen blockers work by either inhibiting estrogen production or blocking its effects on the body's tissues and receptors. Some supplements inhibit the activity of the enzyme aromatase, which converts testosterone into estrogen. By reducing aromatase activity, they can help lower estrogen levels. Others work by binding to estrogen receptors, preventing estrogen from attaching and exerting its effects.

Q: Can estrogen blockers increase testosterone in males?

A: Yes, estrogen blockers can potentially increase testosterone levels in males. Estrogen and testosterone are closely interconnected in the body, with testosterone being converted into estrogen through the process of aromatization. By inhibiting the activity of aromatase, which is responsible for this conversion, estrogen blockers can reduce the conversion of testosterone into estrogen and potentially increase testosterone levels.

Q: Why does estrogen level rise?

A: Elevated estrogen levels can result from hormonal imbalances, excess body fat, certain medications or therapies, exposure to endocrine disruptors, certain medical conditions, and the natural aging process. Hormonal imbalances and adipose tissue can contribute to increased estrogen production. Medications containing estrogen, environmental factors, and specific medical conditions can also cause estrogen levels to rise.


In conclusion, estrogen plays a vital role in the body, influencing reproductive processes, secondary sexual characteristics, and various physiological functions. However, imbalances in estrogen levels can lead to symptoms and health issues. Estrogen blocker supplements offer a potential solution by helping to regulate estrogen levels and restore hormonal balance. These supplements work by inhibiting estrogen production or blocking its effects on the body's tissues and receptors.

Maintaining optimal estrogen levels is essential for overall well-being, and the use of estrogen blocker supplements may be a valuable tool in achieving hormonal balance. It is important to note that the use of estrogen blocker supplements should be approached with caution and under the guidance of a healthcare expert. They can provide personalized advice, monitor hormone levels, and ensure the appropriate use of supplements. Remember to always consult your health professional before starting any supplement. 


  1. Trans-Resveratrol 50%: Journal of Biological Chemistry, Gehm et al., 1997 - The study found that resveratrol can act as an estrogen agonist under certain conditions.
  2. Boron/Boron Glycinate: Environmental Health Perspectives, Nielsen, 1998 - The study suggested that boron can influence the metabolism of steroid hormones, including estrogen.
  3. Zinc: Biological Trace Element Research, Prasad et al., 1996 - The study suggested that zinc might play a role in modulating serum testosterone levels.
  4. Long Jack (Eurycoma longifolia): Journal of the International Society of Sports Nutrition, Tambi MI et al., 2012 - The study suggested that Long Jack might increase serum testosterone in men.
  5. Shilajit: Andrologia, Biswas et al., 2010 - The study found that Shilajit might improve testosterone levels in healthy volunteers.
  6. Chrysin: Biochemical Pharmacology, Kellis and Vickery, 1984 - The study found that chrysin has an anti-estrogenic effect, blocking the enzyme that converts androgens into estrogens.
  7. Indole-3-carbinol: The Journal of Nutrition, Michnovicz and Bradlow, 1990 - The study found that Indole-3-carbinol can alter estrogen metabolism and may have anti-carcinogenic effects.

Written and Sponsored by Leonard Shemtob

Leonard Shemtob is President of Strong Supplements. Leonard has been in the supplement space for over 20 years, specializing in fitness supplements and nutrition. Leonard appears on many podcasts, written over 100 articles about supplements and has studied nutrition, supplementation and bodybuilding. 

Leonard's articles have been published in many top publications around the web. Leonard enjoys weight training, playing basketball and yoga, and also enjoys hiking. In his free time he studies and works on improving himself. For more detailed information, visit his official blog.

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