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​5 Best Supplements for Estrogen Dominance in 2024

​5 Best Supplements for Estrogen Dominance in 2024

Posted by Leonard Shemtob on Jul 01, 2024

Estrogen dominance is a condition where the body has too much estrogen compared to other hormones, especially progesterone. This hormonal imbalance can result in a variety of symptoms, including painful periods, weight gain, mood swings, fatigue, and more.

Managing estrogen dominance is crucial for maintaining overall health and well-being. One effective way to address this issue is through the use of natural supplements. 

In this article, we'll explore the best supplements for estrogen dominance, how they work, and the benefits they offer in restoring hormonal balance. 

Whether you're experiencing symptoms of estrogen dominance or looking to prevent it, these supplements can be a valuable addition to your health regimen.

[Related Article] The Ultimate Guide to Estrogen Blockers for Men in 2024

Short Summary

  • Estrogen Dominance Explained: When estrogen levels are high relative to progesterone, it can disrupt hormonal balance, leading to various health concerns.
  • Causes and Symptoms: Common causes include poor diet, stress, environmental toxins, and hormonal imbalances. Symptoms can include weight gain, fatigue, mood swings, irregular menstrual cycles, and breast tenderness.
  • Diagnosing Estrogen Dominance: Discusses methods for diagnosing estrogen dominance, including medical tests and recognizing symptoms.
  • Treatment Options: Lifestyle changes like managing stress and dietary modifications might be recommended. In certain cases, your doctor may suggest medications.
  • Effective Supplements: Highlights the top supplements for estrogen dominance, such as Terminate, Rebirth, and Letrone, detailing their benefits and ingredients.

What is Estrogen Dominance?

Estrogen is a hormone that plays a major role in the development and regulation of the female reproductive system. It is also found in smaller amounts in males. Estrogen helps control the menstrual cycle, promotes the growth of breast tissue, and influences various aspects of bone health. 

Beyond reproductive functions, estrogen affects mood, cognitive function, and cardiovascular health. It's essential for maintaining overall hormonal balance in the body.

Estrogen dominance is a condition where there is an imbalance between estrogen and progesterone levels in the body. This hormone imbalance occurs when estrogen levels are higher relative to progesterone, disrupting the normal hormonal equilibrium. It can affect both men and women and is associated with various symptoms and health challenges.

Causes of Estrogen Dominance

Exposure to Environmental Estrogens (Xenoestrogens)

Xenoestrogens are synthetic or natural compounds that can mimic the effects of estrogen on the body. These include chemicals found in plastics, personal care products, pesticides, and certain foods. Prolonged exposure to xenoestrogens can disrupt your body's natural hormonal balance and lead to estrogen dominance.

Stress and High Cortisol Levels

Chronic stress can lead to elevated cortisol production, which can interfere with the delicate balance between estrogen and progesterone. High cortisol levels can impair the body's ability to metabolize and eliminate excess estrogen, leading to a relative dominance of estrogen.

Excess Body Fat

Fat tissue actually produces a weak form of estrogen. So, having a higher body fat percentage can contribute to increased estrogen levels.

Liver Issues

The liver is responsible for breaking down and removing excess hormones, including estrogen. If your liver isn't functioning optimally, estrogen levels can build up.

Medications and Hormonal Contraceptives

Some medications, such as certain birth control pills, hormone replacement therapy, and cancer treatments, can disrupt the natural balance of hormones, potentially leading to estrogen dominance.

Signs and Symptoms of Estrogen Dominance

Here are some common signs to watch out for:

  • Irregular Menstrual Periods: Changes in menstrual cycle length, heavy bleeding, or skipped periods.
  • Heavy or painful periods
  • Mood Swings: Increased irritability, anxiety, or depression.
  • Weight Gain: Especially around the hips, thighs, and abdomen.
  • Fatigue: Feeling tired or low energy levels despite adequate rest.
  • Breast Tenderness: Swelling or discomfort in the breasts.
  • Insomnia: Difficulty falling asleep or staying asleep.
  • Decreased Libido: Reduced interest in sexual activity.
  • Infertility and miscarriages
  • Brain Fog: Difficulty concentrating or remembering things.

Risks of Estrogen Dominance

Estrogen dominance can pose several risks to health if left unmanaged. These risks include:

  • Increased Risk of Hormone-Related Cancers: Higher levels of estrogen may contribute to an increased risk of breast, uterine, and ovarian cancers.
  • Endometriosis Risk: This condition involves the growth of uterine tissue outside the uterus. While the exact cause is unknown, estrogen dominance might be a contributing factor.
  • Cardiovascular Issues: Imbalances in estrogen levels can affect cardiovascular health, potentially contributing to heart disease and stroke.
  • Blood Clot Risk: In some cases, estrogen dominance may enhance the risk of blood clots, especially when combined with other risk factors.
  • Uterine Issues: Estrogen dominance can contribute to the development of uterine fibroids, which are noncancerous tumors that can cause pain and bleeding.
  • Polycystic Ovarian Syndrome (PCOS)

How Can I Check My Estrogen Levels?

If you're experiencing symptoms that suggest estrogen dominance, you might be wondering how to confirm it. Here's a breakdown of how estrogen levels are typically checked:

Consulting Your Doctor: The first step is always to talk to your doctor. They can review your symptoms, medical history, and family history to get a clearer picture.

DUTCH Plus Test: This at-home test measures sex and adrenal hormones, and their metabolites, through urine and saliva samples. It provides a detailed analysis of hormone levels and helps identify metabolic and stress-related factors affecting hormonal balance.

Methylation and Micronutrient Panels: These tests assess liver function and nutrient levels. Poor liver function can contribute to estrogen dominance by affecting hormone metabolism. These panels can help identify liver stagnation and nutrient deficiencies.

Comprehensive Stool Test: This test checks for elevated beta-glucuronidase levels and intestinal dysbiosis. High beta-glucuronidase can impair estrogen elimination, while intestinal dysbiosis can further disrupt hormone balance.

Environmental Toxins Screen: If a detailed history doesn't reveal exposure to environmental xenoestrogens (chemicals that mimic estrogen), an environmental toxins screen can quantify exposure to various endocrine-disrupting chemicals.

Thyroid Panel with TBG: Estrogen increases levels of thyroxine-binding globulin (TBG), which binds and transports thyroid hormones. Elevated TBG can lead to a hypothyroid state, and this panel can assess for hypothyroidism due to estrogen dominance.

Vaginosis Panel: For women experiencing symptoms like vaginal itching and discharge, this panel can identify bacterial and yeast overgrowth.

Remember, this test is a tool used by doctors to gain a deeper understanding of your hormonal health. Always consult your doctor to interpret the results and determine the best path forward for you.

Treatment for Estrogen Dominance

Treating estrogen dominance involves a combination of lifestyle changes, dietary adjustments, and possibly medical interventions. Here are some effective approaches:

Lifestyle Changes

These are often the first steps recommended by doctors. They can be incredibly effective in promoting overall well-being and supporting healthy hormone balance. Here are some examples:

  • Dietary Changes: Focusing on whole, unprocessed foods, including plenty of fruits, vegetables, and healthy fats, can make a big difference. Limiting processed foods, sugary drinks, and unhealthy fats can also be beneficial.
  • Weight Management: If you're carrying excess weight, losing some pounds can help regulate estrogen levels because fat tissue produces estrogen.
  • Stress Management: Practice stress-reducing techniques like meditation, yoga, or deep breathing exercises to decrease cortisol levels.
  • Exercise Regularly: Regular physical activity, even moderate exercise most days of the week, can promote healthy hormone levels.

Potential Medications

In some cases, depending on the severity and your specific situation, your doctor might recommend certain medications. This could include hormonal birth control to regulate hormonal levels. 

In addition, they might suggest some anti-inflammatories and antidepressants to address common symptoms related to estrogen domanace such as painful periods and PMS.

Estrogen Detoxification

  • Liver Support: Enhance liver function through a healthy diet, supplements, and avoiding toxins to help process and eliminate excess estrogen.
  • Environmental Toxins: Lower exposure to environmental toxins and xenoestrogens by utilizing natural, chemical-free products.

Targeted Supplements

Specific dietary supplements can help support healthy estrogen metabolism and balance. Some of the most effective supplements discussed in the following section.

Top Supplements for Estrogen Dominance

1- Terminate by Hard Rock Supplements

Terminate by Hard Rock Supplements

Terminate is designed to help reduce estrogen levels, decrease prolactin, and reduce body fat, while also boosting libido. This supplement uses a formula with effective ingredients at optimal dosages to block estrogen and support muscle hardness. Terminate can be used during a cycle to manage estrogen or as a standalone estrogen blocker and muscle hardener.

Key Benefits

  • It reduces estrogen levels.
  • It enhances muscle hardness and libido.
  • It increases your testosterone levels.
  • It improves your strength and vascularity.
  • It helps reduce your body fat.
  • It reduces cortisol levels.

Key Ingredients

  • Trans Resveratrol 50%
  • Androst
  • Boron
  • Boron Glycinate
  • Zinc
  • LongJack
  • Shilajit

Customer Reviews


“This stuff is powerfully. Really tightens me up increase libido increase test and removes estrogen”

-Josh C.

 It works.

“Used toward the end of a cycle and 1 month PCT, kept estrogen levels down, and helped preserve those hard earned gains in muscle. Ordered three more bottles at 10% off for my next three cycles, it worked that well.”



“Excellent product, diffently worth it, ordering two more tomorrow”


2- Rebirth by Black Lion Research

Rebirth by Black Lion Research

After completing an anabolic cycle, restoring normal estrogen levels is crucial for maintaining results. Rebirth from Black Lion Research is a legal selective estrogen receptor modulator (SERM) designed to help balance hormone levels during post-cycle therapy (PCT).

When you finish an anabolic cycle, your hormones, especially estrogen, can be imbalanced. Rebirth works by selectively blocking the negative effects of estrogen while aiding your body in returning estrogen levels to normal.

Key Benefits

  • It blocks estrogen.
  • It supports your PCT recovery.
  • It prevents gyno.

Key Ingredients

  • Ellagic Acid
  • E Cottioni

Customer Reviews

 Rebirth born again PCT

“Very good product period.”


 Great results

“I ran this for a month along with DAA and some herbal and mineral PCT supps, and I feel just fine now.”


 Highly recommend it!

“Highly recommend rebirth... highly recommend strong supplement shop for anything,excellent service,fast shipping”


3- Letrone by Black Lion Research

Letrone by Black Lion Research

Letrone is a potent estrogen blocker and aromatase inhibitor designed to support hormone balance during anabolic cycles. Its key ingredient, Atractylodes Macrocephala, is a natural aromatase inhibitor that helps prevent the conversion of testosterone to estrogen, a common concern during intense anabolic cycles.

Atractylodes Macrocephala also possesses anabolic properties that can potentially enhance natural hormone production and support testosterone levels. This dual action makes Letrone beneficial not only for managing estrogen levels but also for promoting lean muscle development and definition.

Key Benefits

  • It helps reduce estrogen levels.
  • It increases testosterone levels.
  • It reduces body fat.
  • It reduces water retention.
  • It promotes the growth hormone section.
  • It restores test levels during PCT.

Key Ingrdients

  • Atractylodes Macrocephala
  • Naringin
  • Hesperidin
  • Tangeretin
  • Bioperine®

Customer Reviews

 Love this product

“Now that I turn 50 I know my estrogen is getting higher the older I get. This product works perfect for me and my goals”

-Dave G.

 good product

“I'm not prone to excessive estrogen, even when using aromatising PH's, so for me this was super potent. I used half dose for 8 weeks & it worked a treat. I didn't want to crush estro completely, just moderate it on an extended run & into pct. Brilliant, worked a treat & most cost effective at that dose.”


 Strong effects.

“I have been taking Letrone for 3 weeks now and i think this is my new favorite product. Better than some of the lighter prohormone cycles I have run. Im much drier and leaner and my strength is very good. Im gonna stack this with Follidrone next or maybe try Exotherm. I will buy this again for sure.”


4- Erase Pro+ by PEScience

Erase Pro+ by PEScience

Erase Pro+ features Dehydroabietic Acid (DHAA), a potent anti-estrogen ingredient known for reducing estrogen levels, which can lead to decreased body fat and water retention.

Lower estrogen levels also contribute to a simultaneous increase in testosterone, promoting muscle hardness and enhancing vascularity. These combined effects help to achieve a leaner physique with more defined muscle mass.

Key Benefits

  • It increases muscle hardness.
  • It improves overall mood.
  • It enhances your vascularity.
  • It reduces body fat.
  • It helps reduce water retention.
  • It boosts your libido.
  • It increases testosterone levels.

Key Ingredients

  • Ashwagandha Root Extract
  • Indole-3-Carbinol
  • Pink Bark Extract: (DHAA)

Customer Reviews

 The Best Estrogen Controller Ever

“For years, I looked for an over the counter that would control the body fat and bloating and this is it You see the effects right away It chisels out fat from the back, chest and abdominal section Perfect Exactly what I needed”


 Absolutely the Best

“Not only great for removing longstanding cycle effects, but is a great body fat burner. I've noticed reductions in my chest, obliques and lower back. I've regained my overall shape. Definitely a supplement staple from now on.”


 Working great!

“5 stars. Working great. Going to order another bottle”


5- Inhibit-E by Serious Nutrition Solutions

Inhibit-E by Serious Nutrition Solutions

Inhibit-E from Serious Nutrition Solutions is a unique formula designed as an anti-aromatase and anti-estrogen supplement. It aims to lower estrogen levels while promoting higher testosterone levels, supporting a leaner, dryer, and more defined physique.

The ingredients in Inhibit-E effectively inhibit the aromatase enzyme, which can convert testosterone into estrogen. By reducing estrogen levels and maintaining higher testosterone levels, this formula supports muscle definition and overall physical performance.

Key Benefits

  • It reduces estrogen levels.
  • It enhances your strength.
  • It promotes fat loss.
  • It reduces water weight.
  • It increases your testosterone levels.
  • It boosts your libido.

Key Ingredients

  • Brassaiopsis Glomerulata
  • Broussonetia papyrifera
  • Olive Leaf Extract
  • Indole-3-Carbinol
  • Hesperidin
  • Abieta-8,11,13-trien-18-oic acid (extracted from Commiphora myrrha)

Customer Reviews

 Great stuff

“Got leaner,hornier and felt better overall while taking this. And you can't beat the price!!!”


 Awesome product!

“Works great at reducing estrogen for a cycle or post-cycle.”


 crush estrogen

“Inhibit e is very effective. i have used it in both pct and as part of a recomp. The product allows me to crush estrogen and maintain hardness and vascularity on a cut/recomp. It also helped prevent gyno as part of my pct regiment. You don't get the dry joints like you do from arimistane products and this is just as, if not more, effective. Overall it is a great product solo or stacked with others. I highly recommend it.”


Frequently Asked Questions (FAQs)

Q: What are common symptoms of estrogen dominance?

A: Common symptoms include irregular menstrual periods, mood swings, weight gain, fatigue, breast tenderness, insomnia, and brain fog.

Q: What causes estrogen dominance?

A: Causes of estrogen dominance include dietary choices, chronic stress, exposure to environmental toxins, hormonal changes, and poor liver health.

Q: Can men experience estrogen dominance?

A: Yes, men can experience estrogen dominance. Symptoms in men may include weight gain, fatigue, mood swings, and decreased libido.

Q: Can estrogen dominance lead to infertility?

A: Yes, estrogen dominance can contribute to fertility issues by disrupting ovulation and menstrual cycles. Addressing the underlying hormonal imbalance is important for those trying to conceive.

Q: Are there any lifestyle changes that can help manage estrogen dominance?

A: Yes, lifestyle changes such as regular exercise, a healthy diet, stress management, reducing exposure to environmental toxins, and getting adequate sleep can help manage estrogen dominance.


Estrogen dominance is a significant health concern characterized by an imbalance between estrogen and progesterone levels in the body. This imbalance can lead to numerous symptoms, including irregular menstrual cycles, weight gain, mood swings, and fatigue. Managing estrogen dominance is crucial for overall health and well-being.

This article explored the causes, symptoms, and risks associated with estrogen dominance. We discussed effective methods for diagnosing this condition and outlined treatment options ranging from lifestyle changes to targeted supplements. These supplements, such as Terminate, Rebirth, Letrone, Erase Pro+, and Inhibit-E, offer valuable support in restoring hormonal balance.

Consulting a healthcare expert is essential for accurate diagnosis and personalized treatment options. By taking proactive steps, you can achieve better hormonal balance and overall well-being.


Written and Sponsored by Leonard Shemtob

Leonard Shemtob is President of Strong Supplements. Leonard has been in the supplement space for over 20 years, specializing in fitness supplements and nutrition. Leonard appears on many podcasts, written over 100 articles about supplements and has studied nutrition, supplementation and bodybuilding. 

Leonard's articles have been published in many top publications around the web. Leonard enjoys weight training, playing basketball and yoga, and also enjoys hiking. In his free time he studies and works on improving himself. For more detailed information, visit his official blog.